About

After previously being a student assistant at the working group Biometry in Molecular Medicine (led by Prof. Anne-Laure Boulesteix), I joined the group as a PhD student in January 2020. My main focus is on researcher degrees of freedom and over-optimism in gene (set) analysis and method performance evaluation.

I obtained a Bachelor's Degree (B.Sc.) and a Master's Degree (M.Sc.) in Statistics from the Ludwig-Maximilians-University Munich.

Research Interests

• Researcher degrees of freedom and over-optimism
• Differential expression analysis and gene set analysis
• Method performance evaluation

Publications 

Submitted articles

• M. Wünsch, C. Sauer, M. Herrmann, L. C. Hinske, A.-L. Boulesteix, 2024. To tweak or not to tweak. How exploiting flexibilities in gene set analysis leads to over-optimism. arXiv preprint arXiv:2402.00754.

Peer-reviewed articles                              

• M. Wünsch, C. Sauer, P. Callahan, L. C. Hinske, A.-L. Boulesteix, 2024. From RNA sequencing measurements to the final results: A practical guide to navigating the choices and uncertainties of gene set analysis. WIREs Computational Statistics, 16(1):e1643.
  
• C. Nießl, S. Hoffmann, T. Ullmann, A.-L. Boulesteix (2024). Explaining the optimistic performance evaluation of newly proposed methods: A cross-design validation experiment. Biometrical Journal, 66(1):2200238.
  
• C. Nießl, M. Herrmann, C. Wiedemann, G. Casalicchio, A.-L. Boulesteix (2022). Over-optimism in benchmark studies and the multiplicity of design and analysis options when interpreting their results. Wiley Interdisciplinary Reviews: Data Mining and Knowledge Discovery, 12(2):e1441.
• C. Nießl, A.-L. Boulesteix, J. Oh, K. Palm, P. Schlingmann, S. Wygoda, D. Haffner, E. Wühl, B. Tönshoff, A. Buescher, H. Billing, B. Hoppe, M. Zirngibl, M. Kettwig, K. Moeller, B. Acham-Roschitz, K. Arbeiter, M. Bald, M. Benz, M. Galiano, U. John-Kroegel, G. Klaus, D. Marx-Berger, K. Moser, D. Mueller, L. Patzer, M. Pohl, B. Seitz, U. Treikauskas, R. O. von Vigier, W. A. Gahl, K. Hohenfellner (2022). Relationship between age at initiation of cysteamine treatment, adherence with therapy, and glomerular kidney function in infantile nephropathic cystinosis. Molecular Genetics and Metabolism, 136(4):268-273.
• K. Hohenfellner, C. Nießl, D. Haffner, J. Oh, C. Okorn, K. Palm, K.-P. Schlingmann, S. Wygoda, W. A. Gahl (2022). Beneficial effects of starting oral cysteamine treatment in the first 2 months of life on glomerular and tubular kidney function in infantile nephropathic cystinosis. Molecular Genetics and Metabolism, 136(4):282-288.